A Novel Methodology for Applying Multivoxel MR Spectroscopy to Evaluate Convection-Enhanced Drug Delivery in Diffuse Intrinsic Pontine Gliomas.

D I Guisado Ranjodh S Boparai S Minkowitz Zhiping Zhou Sofia S Haque Kyung K Peck Robert J Young A John Tsiouris Mark M Souweidane Sunitha B Thakur

Published in: AJNR. American journal of neuroradiology (2016)

The comparative change in metabolite ratios between the convection-enhanced delivery site and the tumor site outside the infused area suggests that multivoxel (1)H-MR spectroscopy, in combination with other imaging modalities, may provide a clinical tool to accurately evaluate local tumor response after convection-enhanced delivery treatment.

Keyphrases

high resolution
drug delivery
single molecule
magnetic resonance
contrast enhanced
high grade
low grade
magnetic resonance imaging
solid state
computed tomography
combination therapy
photodynamic therapy
smoking cessation