Enantioselective Synthesis of [6]Carbohelicenes.
Elisa González-FernándezLeo D M NichollsLukas D SchaafChristophe FarèsChristian W LehmannManuel AlcarazoPublished in: Journal of the American Chemical Society (2017)
The use of α-cationic phosphonites derived from TADDOL as ancillary ligands has allowed a highly regio- and enantioselective synthesis of substituted [6]carbohelicenes by sequential Au-catalyzed intramolecular hydroarylation of diynes. Key for these results is the modular structure of these new ligands, and the enhanced reactivity that they impart to Au(I)-centers after coordination.