Ferroptosis-Related lncRNAs Act as Novel Prognostic Biomarkers in the Gastric Adenocarcinoma Microenvironment, Immunotherapy, and Chemotherapy.
Yushi ZhengShanshan WuXueshan HuangLian-Xiang LuoPublished in: Oxidative medicine and cellular longevity (2023)
Ferroptosis, a form of programmed cell death akin to necrosis, is managed by iron and is distinguished by lipid peroxidation. Gastric cancer is a highly aggressive form of cancer, responsible for the third highest number of cancer-related deaths globally. Despite this, the potential of ferroptosis to predict the occurrence of this cancer is yet to be determined. In this research, a comprehensive examination was conducted to explore the link between long noncoding RNAs (lncRNAs) and ferroptosis, in order to uncover an lncRNA signature that can predict drug susceptibility and tumor mutational burden (TMB) in gastric adenocarcinoma. We conducted an in-depth analysis of the GC immune microenvironment and immunotherapy, with a particular focus on ferroptosis-related lncRNA prognostic biomarkers, and further explored the correlation between these factors and prognosis, immune infiltration, single nucleotide variation (SNV), and drug sensitivity for gastric adenocarcinoma patients. Through our investigations, we have discovered five lncRNA signatures related to ferroptosis that can accurately forecast the prognosis of gastric adenocarcinoma patients and also regulate the proliferation, migration, and occurrence of ferroptosis in gastric adenocarcinoma cells. In conclusion, this lncRNA signature associated with ferroptosis may be employed as a prognostic indicator for gastric adenocarcinoma, thus presenting a potential solution.
Keyphrases
- cell death
- squamous cell carcinoma
- locally advanced
- end stage renal disease
- cell cycle arrest
- ejection fraction
- chronic kidney disease
- newly diagnosed
- long non coding rna
- papillary thyroid
- prognostic factors
- stem cells
- risk assessment
- long noncoding rna
- gene expression
- radiation therapy
- peritoneal dialysis
- patient reported outcomes
- oxidative stress
- squamous cell
- high resolution
- climate change
- cell proliferation
- simultaneous determination