Interferon Alpha-Expressing Oncolytic Adenovirus for Treatment of Esophageal Adenocarcinoma.

Christopher J LaRoccaAmanda O SalzwedelMizuho Sato-DahlmanMargarita V RomanenkoRafael AndradeJulia DavydovaMasato Yamamoto

Published in: Annals of surgical oncology (2021)

An IFN-expressing CRAd driven by the Cox2 promoter has strong oncolytic effects as well as cancer-specific replication. Our novel vector possesses critical characteristics that make it a potential candidate for clinical translation to treat EAC.

Keyphrases

dendritic cells
papillary thyroid
dna methylation
squamous cell carcinoma
immune response
gene expression
transcription factor
squamous cell
lymph node metastasis
human health
young adults
risk assessment
radiation therapy
gene therapy
rectal cancer