Physiologically-based pharmacokinetics modeling of Semaglutide in children and adolescents with healthy and obese body weights.
Thayná Rocco MachadoThiago HonorioThaisa F Souza DomingosDailane da Silva Candido de PaulaLucio Mendes CabralCarlos R RodriguesBárbara A Abrahim-VieiraAlessandra Mendonça Teles de SouzaPublished in: British journal of clinical pharmacology (2023)
Pediatric PBPK was successfully achieved using a top-down approach and drug-related parameters. The development of unprecedented PBPK models will support pediatric clinical therapy for applying aid-safe dosing regimens for the pediatric population in diabetes treatment.