STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases.

Phuong Tran PhamDaiju FukudaSachiko NishimotoJoo-Ri Kim-KaneyamaXiao-Feng LeiYutaka TakahashiTomohito SatoKimie TanakaKumiko SutoYutaka KawabataKoji YamaguchiShusuke YagiKenya Kusunose Hirotsugu YamadaTakeshi SoekiTetsuzo WakatsukiKenji ShimadaYasuhisa KanematsuYasushi TakagiMichio ShimabukuroMitsutoshi SetouGlen N BarberMasataka Sata

Published in: European heart journal (2021)

Stimulator of interferon genes stimulates pro-inflammatory activation of macrophages, leading to the development of atherosclerosis. Stimulator of interferon genes signalling may serve as a potential therapeutic target for atherosclerosis.

Keyphrases

cardiovascular disease
genome wide
dendritic cells
bioinformatics analysis
oxidative stress
genome wide identification
metabolic syndrome
circulating tumor
physical activity
single molecule
type diabetes
gene expression
risk assessment
immune response