METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors.

Alessia IaizaClaudia TitoZaira IannielloFederica GanciValentina LaquintanaEnzo GalloAndrea SacconiSilvia MasciarelliLuciana De AngelisSara AversaDaniele DisoMarco AnileVincenzo PetrozzaFrancesco FaccioloEnrico MelisEdoardo PescarmonaFederico VenutaMirella MarinoGiovanni BlandinoGiulia FontemaggiAlessandro FaticaFrancesco Fazi

Published in: Clinical epigenetics (2021)

This study highlighted METTL3 as a tumor promoter in Thymic tumors and c-MYC as a promising target to be exploited for the treatment of TET.

Keyphrases

dna methylation
gene expression
transcription factor
replacement therapy