Impaired dendritic spike generation in the Fragile X prefrontal cortex is due to loss of dendritic sodium channels.

and dendritic HCN-channel function is reduced in ET neurons, we suggest that dendritic integration by PFC circuits is fundamentally altered in Fragile X syndrome. Abstract figure legend Loss of dendritic sodium conductance in layer 5 ET neurons in the prefrontal cortex of Fragile X mice. Dendritic sodium channels are critical to the generation of sodium spikes in the dendrites of layer 5 pyramidal neurons in the mouse prefrontal cortex. In L5 PFC neurons of FX mice (red) the threshold for dendritic sodium spikes is depolarized due to a reduced dendritic sodium conductance. This article is protected by copyright. All rights reserved.