Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies.

Neil A J Ryan Thomas D J WalkerJames BoltonNatalja Ter HaarJ Tom van WezelMark A GlaireDavid N ChurchDafydd Gareth EvansTjalling BosseEmma J Crosbie

Published in: Cancers (2021)

Whilst MMRd EC of hereditary and sporadic aetiology may be difficult to distinguish by histology alone, differences in infiltrating immune cell counts and mutational profile may predict heterogenous responses to novel targeted therapies and warrant further study.

Keyphrases

late onset
copy number
endometrial cancer
gene expression
peripheral blood
early onset
wild type