Characterization of the novel plasmid-encoded MBL gene blaAFM-1, integrated into a blaIMP-45-bearing transposon Tn6485e in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate.
Xuefei ZhangLeilei WangDan LiChen WangQinglan GuoMinggui WangPublished in: The Journal of antimicrobial chemotherapy (2021)
The blaAFM-1 gene confers carbapenem resistance and has been captured in distinct species of non-fermenters. Co-carriage of blaAFM-1 and blaIMP-45 in an MDR transposon on a conjugative plasmid can be expected to promote further dissemination of blaMBLs.
Keyphrases
- pseudomonas aeruginosa
- escherichia coli
- acinetobacter baumannii
- copy number
- genome wide
- multidrug resistant
- crispr cas
- genome wide identification
- cystic fibrosis
- klebsiella pneumoniae
- gram negative
- biofilm formation
- drug resistant
- gene expression
- dna methylation
- transcription factor
- microbial community
- genetic diversity
- candida albicans