New Alpiniamide-Type Polyketide with Antibiofilm Activities from the Marine-Derived Streptomyces sp. ZS-A65.

Fanqi PuJiebin FangWenshuo LiBin ZhangXinyi HongLei XuXihui LiYongjun Jiang

Published in: Chemistry & biodiversity (2024)

Two new alpiniamide-type polyketides, alpiniamides H-I (1-2), in addition to four recognized compounds, were discovered in Streptomyces sp. ZSA65 derived from the marine sediments. The planar structure and absolute configuration of alpiniamides H-I were elucidated using a combination of 1D, 2D NMR, HRESIMS data analysis, Mosher's method and ECD calculations. The antibiofilm and antibacterial activities against P. aeruginosa were evaluated using the microdilution method. Notably, Compound 2 exhibited strong antibiofilm property.

Keyphrases

data analysis
heavy metals
magnetic resonance
high resolution
molecular dynamics
density functional theory
molecular dynamics simulations
risk assessment
polycyclic aromatic hydrocarbons
solid state