Pharmacogenomic study of gemcitabine efficacy in patients with metastatic pancreatic cancer: A multicenter, prospective, observational cohort study (GENESECT study).
Masahiro HatoriDaiki TsujiKenichi SuzukiTakashi YokokawaKazuyoshi KawakamiRyo MoriyamaMarika Osada-TsuchiyaAki OtakeMasahiko NakaoTakuya YanoYuichiro ArakawaKeisuke MatsuoYasukata OhashiYasuhiko SakataYuki KogureShinya TamakiAtsushi WadaYusuke TakiNaoki SasahiraHiroshi IshiiMasakazu YamaguchiKunihiko ItohPublished in: Cancer (2024)
Genetic polymorphisms from the pharmacokinetics of gemcitabine did not indicate a significant association with efficacy, but COX-2 polymorphisms involved in tumor cell proliferation might affect OS.