Selective Determination of Entecavir in the Presence of its Oxidative Degradate by Spectrophotometric and Chromatographic Methods.

Heba M El-SayedLaila E Abdel FattahHisham E AbdellatefMaha A HegazyHeba M El-Sayed

Published in: Journal of AOAC International (2021)

ENT was quantified using two spectrophotometric (D2 and MCR) methods and an HPLC method in presence of ENT deg. The proposed methods were applied to analysis of ENT tablets with high selectivity, sensitivity, and accuracy.

Keyphrases

simultaneous determination
solid phase extraction
escherichia coli
ms ms
high performance liquid chromatography
tandem mass spectrometry
mass spectrometry
liquid chromatography
high resolution