The landscape of PBMCs in AQP4-IgG seropositive NMOSD and MOGAD, assessed by high dimensional mass cytometry.

Mengyuan YaoWenjing WangJiali SunTianshu GuoJiangping BianFuyao XiaoYuanyuan LiHengri CongYuzhen WeiXinghu ZhangJianghong LiuLinlin Yin

Published in: CNS neuroscience & therapeutics (2024)

Our findings describe the whole landscape of PBMCs in two similar demyelinated diseases and suggest that, besides MNPs, T, NK and B, cells were all involved in the pathogenesis. The identified cell population may be used as a predictor for monitoring disease development or treatment responses.

Keyphrases

single cell
mesenchymal stem cells
combination therapy
bone marrow
replacement therapy
nk cells