Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis.

E XiangBing HanQuan ZhangWei RaoZhangfan WangCheng ChangYaqi ZhangChengshu TuChangyong LiDongcheng Wu

Published in: Stem cell research & therapy (2020)

UC-MSCs can effectively improve the renal function, inhibit inflammation and fibrosis, and prevent its progression in a model of diabetes-induced chronic renal injury, indicating that UC-MSCs could be a promising treatment strategy for DN.

Keyphrases

umbilical cord
mesenchymal stem cells
diabetic nephropathy
oxidative stress
endothelial cells
diabetic rats
high glucose
type diabetes
cardiovascular disease
bone marrow
signaling pathway
glycemic control
induced pluripotent stem cells
liver fibrosis
skeletal muscle