Relation of Quantitative Histologic and Radiologic Breast Tissue Composition Metrics With Invasive Breast Cancer Risk.
Mustapha AbubakarShaoqi FanErin J Aiello BowlesLea WidemannMáire A DugganRuth M PfeifferRoni T FalkScott LawrenceKathryn Richert-BoeAndrew G GlassTeresa M KimesJonine D FigueroaThomas E RohanGretchen L GierachPublished in: JNCI cancer spectrum (2021)
Among BBD patients, increasing epithelium-to-stroma proportion on BBD biopsies and percent MBD at BBD diagnosis were independently and jointly associated with increasing breast cancer risk. These findings were particularly striking for women with nonproliferative disease (comprising approximately 70% of all BBD patients), for whom relevant predictive biomarkers are lacking.