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Selective inhibition of steroidogenic enzymes by ketoconazole in rat ovary cells.

Michael GalJoseph Orly
Published in: Clinical medicine insights. Reproductive health (2014)
These findings map the effects of KCZ on the ovarian pathways of progestin, androgen, and estrogen synthesis. Hence, the drug may have a potential use as an acute and reversible modulator of ovarian steroidogenesis in pathological circumstances.
Keyphrases
  • induced apoptosis
  • liver failure
  • cell cycle arrest
  • drug induced
  • oxidative stress
  • respiratory failure
  • endoplasmic reticulum stress
  • estrogen receptor
  • signaling pathway
  • pi k akt
  • acute respiratory distress syndrome