Overexpression of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in boys with cryptorchidism.

Dorota Toliczenko-BernatowiczEwa MatuszczakMarzena TylickaBeata SzymańskaMarta KomarowskaEwa GorodkiewiczWojciech DebekAdam Hermanowicz

Published in: PloS one (2018)

Uchl1 concentrations in the blood plasma of boys with cryptorchidism, may reflect the heat-induced apoptosis of germ cells. Higher UCHL1 concentrations in older boys with undescended testicles, probably express intensity of germ cell apoptosis, more extensive when testicles are subjected to heat-stress for longer period. Further analyses of UCHL1 may help to elucidate its role in mechanisms influencing spermatogenesis.

Keyphrases

induced apoptosis
heat stress
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell proliferation
heat shock
transcription factor
small molecule
physical activity
middle aged
community dwelling
cell cycle arrest