Unveiling dynamics of nitrogen content and selected nitrogen heterocycles in thrombin inhibitors: a ceteris paribus approach.
Vijay H MasandSami Al-HussainAbdullah Y AlzahraniAamal A Al-MutairiArwa Sultan AlqahtaniAbdul SamadAhmed M AlafeefyRahul D JawarkarMagdi E A ZakiPublished in: Expert opinion on drug discovery (2024)
The majority of active thrombin inhibitors contain nitrogen atoms close to 5 and a combination of N-heterocycles like pyrrolidine, pyridine, piperidine, etc. This analysis provides crucial insights to optimize the transformation of lead compounds into potential anti-thrombin inhibitors.
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