Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy.

Luis Enrique MunozLei HuangRamireddy BommireddyRicha SharmaLenore MonterrozaRohini N GuinSarah G SamaranayakeChristopher D PackSampath RamachandiranShaker J C ReddyMala ShanmugamPeriasamy Selvaraj

Published in: Journal for immunotherapy of cancer (2021)

Our data suggest that metformin can synergize with vaccine immunotherapy to augment the antitumor response through tumor-intrinsic mechanisms and also alter the phenotype and function of CD8 T cells within the tumor, which could provide insights for its use in the clinic.

Keyphrases

immune response
primary care
electronic health record
big data
dendritic cells
toll like receptor
inflammatory response
deep learning
data analysis