Efficacy of T-Cell Receptor-Based Adoptive Cell Therapy in Cutaneous Melanoma: A Meta-Analysis.
Ramón YarzaMateo BoverMercedes Herrera-JuarezMacarena Rey-CardenasLuis Paz-AresJose A Lopez-MartinJohn HaanenPublished in: The oncologist (2023)
TCR-T therapy shows promising results in terms of antitumor activity and survival similar to those reported for TILs with a significantly higher benefit for cancer/testis antigens targeting cells. Since TCR-based therapy shows advantages of great potential over classic ACT strategies, further research in solid cancers is warranted (PROSPERO ID CRD42022328011).
Keyphrases
- cell therapy
- stem cells
- induced apoptosis
- regulatory t cells
- mesenchymal stem cells
- papillary thyroid
- cell cycle arrest
- dendritic cells
- cancer therapy
- cell death
- squamous cell carcinoma
- immune response
- drug delivery
- young adults
- oxidative stress
- binding protein
- lymph node metastasis
- signaling pathway
- smoking cessation
- skin cancer