F-cells promote Plasmodium falciparum proliferation in sickle cell disease.

Natasha M ArcherBénédicte GnangnonMahmoud MikdarMarioara F CiuculescuNicole PetersenSteven J StaffaManoj T Duraisingh

Published in: American journal of hematology (2023)

HbF modifies P. falciparum infection in HbSS RBCs, further highlighting the complexity of the molecular interactions between these two diseases. Other inhibitors of HbS polymerization that do not increase HbF or F-cells should be independently assessed for their effects on P. falciparum malaria proliferation in HbSS RBCs.

Keyphrases

plasmodium falciparum
induced apoptosis
sickle cell disease
signaling pathway
cell cycle arrest
oxidative stress
cell proliferation
pi k akt