Resveratrol May Reduce the Degree of Periodontitis by Regulating ERK Pathway in Gingival-Derived MSCs.
Han JiangJia NiLongshuang HuZichao XiangJincheng ZengJiejun ShiQianming ChenWen LiPublished in: International journal of molecular sciences (2023)
Gingival-derived mesenchymal stem cells (GMSCs) have strong self-renewal, multilineage differentiation, and immunomodulatory properties and are expected to be applied in anti-inflammatory and tissue regeneration. However, achieving the goal of using endogenous stem cells to treat diseases and even regenerate tissues remains a challenge. Resveratrol is a natural compound with multiple biological activities that can regulate stem cell immunomodulation when acting on them. This study found that resveratrol can reduce inflammation in human gingival tissue and upregulate the stemness of GMSCs in human gingiva. In cell experiments, it was found that resveratrol can reduce the expression of TLR4, TNFα, and NFκB and activate ERK/Wnt crosstalk, thereby alleviating inflammation, promoting the proliferation and osteogenic differentiation ability of GMSCs, and enhancing their immunomodulation. These results provide a new theoretical basis for the application of resveratrol to activate endogenous stem cells in the treatment of diseases in the future.
Keyphrases
- stem cells
- signaling pathway
- cell therapy
- endothelial cells
- oxidative stress
- mesenchymal stem cells
- pi k akt
- cell proliferation
- anti inflammatory
- induced pluripotent stem cells
- rheumatoid arthritis
- immune response
- gene expression
- inflammatory response
- single cell
- toll like receptor
- nuclear factor
- bone marrow
- epithelial mesenchymal transition
- combination therapy