New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box® that present synergism with itraconazole.
Rowena Alves CoelhoGabriela Machado AlvesMaria Helena Galdino Figueiredo-CarvalhoFernando Almeida-SilvaGabriela Rodrigues de SouzaMaria Cristina da Silva LourençoFábio Brito-SantosAna Claudia Fernandes AmaralRodrigo Almeida-PaesPublished in: Memorias do Instituto Oswaldo Cruz (2022)
These compounds in combination, particularly SQ109, are promising candidates to treat Fonsecaea spp. and E. dermatitidis infections, which account for most cases of chromoblastomycosis and phaeohyphomycosis.