FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence.

Charles FouilladeSandra Curras-AlonsoLorena GiurannoEddy QuelennecSophie HeinrichSarah Bonnet-BoissinotArnaud BeddokSophie Leboucher Hamza Umut KarakurtMylène BohecSylvain Baulande Marc A VooijsPierre VerrelleMarie Dutreix José-Arturo Londono-VallejoVincent Favaudon

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

The results suggest that, compared with conventional radiotherapy, FLASH minimizes DNA damage in normal cells, spares lung progenitor cells from excessive damage, and reduces the risk of replicative senescence.

Keyphrases

dna damage
oxidative stress
induced apoptosis
diabetic rats
dna repair
endothelial cells
high glucose
radiation induced
early stage
cell cycle arrest
risk factors
stress induced
locally advanced
signaling pathway
drug induced
body mass index
weight loss