ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice.

Mohan BabuDurga DeviPetri MäkinenTiit ÖrdEinari Aavik Minna U Kaikkonen Suo Ctc Bladder Committee

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

Our results suggest that an impaired collateral remodeling and sprouting angiogenesis in T2DM mice is associated with persistent IFN-I response in ECs and Mϕs. Dampening persistent inflammation and skewing ECs and Mϕ phenotype toward less inflammatory ones using rHDL nanotherapy may serve as a potential therapeutic target for T2DM peripheral arterial disease.

Keyphrases

endothelial cells
oxidative stress
immune response
adipose tissue
dendritic cells
vascular endothelial growth factor
glycemic control
high fat diet induced
high glucose
mouse model
human health
risk assessment
wild type