Microbiota-Driven Activation of Intrahepatic B Cells Aggravates NASH Through Innate and Adaptive Signaling.

Fanta BarrowSaad KhanGavin FredricksonHaiguang WangKatrina DietschePreethy ParthibanSacha RobertThomas KaiserShawn WinerAdam HermanOyedele AdeyiMarialena MouzakiAlexander KhorutsKristin A HogquistChristopher M StaleyDaniel A WinerXavier S Revelo

Published in: Hepatology (Baltimore, Md.) (2022)

Our findings reveal that a gut microbiota-driven activation of intrahepatic B cells leads to hepatic inflammation and fibrosis during the progression of NASH through innate and adaptive immune mechanisms.

Keyphrases

immune response
oxidative stress
genome wide
single cell
gene expression
dna methylation