Additional Oncogenic Alterations in RAS-Driven Differentiated Thyroid Cancers Associate with Worse Clinicopathologic Outcomes.

Athanasios Bikas Sara Ahmadi Theodora Pappa Ellen Marqusee Kristine S Wong Matthew A Nehs Nancy L Cho Jacob Haase Gerard M Doherty Kartik Sehgal Justine A Barletta Erik K Alexander Iñigo Landa

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Identification of key additional mutations in patients with RAS-mutant thyroid cancers confers a more aggressive phenotype, increases mortality risk in DTC, and can explain the diversity of RAS-mutated thyroid neoplasia. These data support genomic profiling of DTCs to inform prognosis and clinical decision making.

Keyphrases

wild type
decision making
high grade
single cell
big data
transcription factor
electronic health record
adipose tissue
skeletal muscle
gene expression
childhood cancer
weight loss
data analysis