An integrated in silico analysis highlighted angiogenesis regulating miRNA-mRNA network in PCOS pathophysiology.

Srabani Mukherjee Shaini JosephJatin ShahSrabani Mukherjee

Published in: Journal of assisted reproduction and genetics (2022)

By in silico analysis, we identified crucial dysregulated angiogenesis-related genes, the miRNA-mRNA interactions, and signaling pathways involved in impaired follicular angiogenesis in PCOS. This work provides a novel insight into the mechanism of aberrant ovarian angiogenesis contributing to PCOS pathophysiology.

Keyphrases

endothelial cells
vascular endothelial growth factor
polycystic ovary syndrome
wound healing
signaling pathway
molecular docking
type diabetes
cell proliferation
induced apoptosis