A Systematic Review of Treatment and Outcomes of Pregnant Women With COVID-19-A Call for Clinical Trials.
Katelyn A PastickMelanie R NicolElizabeth SmythRebecca ZashDavid R BoulwareRadha RajasinghamEmily Gibson McDonaldPublished in: Open forum infectious diseases (2020)
There are limited published reports of COVID-19 in pregnancy despite more than 14 million cases worldwide. To date, clinical outcomes appear reassuring, but data related to important long-term outcomes are missing or not yet reported. The large number of clinical trials excluding pregnant persons, despite interventions with safety data in pregnancy, is concerning. In addition to observational cohort studies, pregnancy-specific adaptive clinical trials could be designed to identify safe and effective treatments.
Keyphrases
- clinical trial
- pregnant women
- pregnancy outcomes
- coronavirus disease
- sars cov
- preterm birth
- electronic health record
- phase ii
- big data
- machine learning
- double blind
- respiratory syndrome coronavirus
- adverse drug
- smoking cessation
- insulin resistance
- adipose tissue
- replacement therapy
- deep learning
- glycemic control
- meta analyses