Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma.

Openshaw M RAli A MohamedBarbara OttoliniDaniel Fernandez-GarciaCathy J RichardsKaren PageDavid S GutteryAnne L ThomasJacqui A Shaw

Published in: British journal of cancer (2020)

Sensitive ctDNA detection allows disease monitoring and prediction of short OS in metastatic patients. Presence of ctDNA postoperatively predicts relapse and defines a 'molecular relapse' before overt clinical disease. This lead time defines a potential therapeutic window for additional anticancer therapy.

Keyphrases

circulating tumor
squamous cell carcinoma
free survival
newly diagnosed
ejection fraction
loop mediated isothermal amplification
small cell lung cancer
real time pcr
prognostic factors
single molecule
stem cells
radiation therapy
circulating tumor cells
mesenchymal stem cells
sensitive detection