Control of glutamate release by complexes of adenosine and cannabinoid receptors.

Attila KöfalviEstefanía MorenoArnau CordomíNing-Sheng CaiVictor Fernández-DueñasSamira G FerreiraRamón Guixà-GonzálezMarta Sánchez-SotoHideaki YanoVerònica Casadó-AngueraRodrigo A CunhaAna Maria SebastiãoFrancisco CiruelaLeonardo PardoVicent CasadóSergi Ferré

Published in: BMC biology (2020)

We demonstrate that the well-established cannabinoid-induced inhibition of striatal glutamate release can mostly be explained by a CB1R-mediated counteraction of the A2AR-mediated constitutive activation of adenylyl cyclase in the A2AR-CB1R heteromer.

Keyphrases

high glucose
diabetic rats
functional connectivity
oxidative stress
drug induced
protein kinase