Vedolizumab Efficacy Is Associated With Decreased Intracolonic Dendritic Cells, Not Memory T Cells.

Elisa K BodenRamya KongalaDuncan C HindmarchDonna M ShowsJulius G JuarezJames D Lord

Published in: Inflammatory bowel diseases (2023)

The clinical effects of vedolizumab reveal integrin α4β7-dependent dendritic cell migration to the intestinal mucosa to be central to inflammatory bowel disease pathogenesis.

Keyphrases

cell migration
ulcerative colitis
dendritic cells
patients with inflammatory bowel disease
immune response
regulatory t cells
genome wide
working memory
single cell
gene expression
dna methylation