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Insight into the Structure and Physicochemical Properties of Potent Chemokine Receptor 5 Inhibitors for the Discovery of Novel Alzheimer's Disease Drugs.

Nur Intan Saidaah Mohamed YusofNor Atirah AwaluddinFazlin Mohd Fauzi
Published in: Central nervous system agents in medicinal chemistry (2023)
Future studies should include analyses of the analogues or derivatives of the representative compounds to further expand on the findings here and establish the structure-activity relationship for CCR5 inhibition. This would aid in the development of new AD drugs since drug discovery and development of AD drugs are suffering from high attrition.
Keyphrases
  • structure activity relationship
  • drug discovery
  • small molecule
  • cognitive decline
  • high throughput
  • current status
  • case control
  • binding protein
  • anti inflammatory