The dual role of group V secretory phospholipase A2 in pancreatic β-cells.

Preetha ShridasVictoria P NoffsingerAndrea C TrumbauerNancy R Webb

Published in: Endocrine (2017)

Deficiency of GV sPLA2 results in diminished GSIS in isolated pancreatic beta-cells. However, the reduced GSIS in islets lacking GV sPLA2 appears to be compensated by increased islet mass in GV KO mice.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
type diabetes
oxidative stress
metabolic syndrome
adipose tissue
skeletal muscle
smoking cessation
wild type