Stiffness- and Bioactive Factor-Mediated Protection of Self-Assembled Cartilage against Macrophage Challenge in a Novel Co-Culture System.
Ryan P DonahueJarrett M LinkVijaykumar S MeliJerry C HuWendy F LiuKyriacos A AthanasiouPublished in: Cartilage (2022)
In conclusion, neocartilage stiffness can mediate macrophage behavior, but stiffness and bioactive factors prevent macrophage-induced degradation. Ultimately, this co-culture system could be utilized for additional studies to develop the burgeoning field of cartilage mechano-immunology.