Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice.

Stef De LombaerdeSara NeytKen KersemansJeroen VerhoevenLindsey DevisscherHans Van VlierbergheChristian VanhoveFilip De Vos

Published in: PloS one (2017)

A 18F labeled bile acid analogue, [18F]FCA, has been developed that shows transport by NTCP, OATP, MRP2 and BSEP. [18F]FCA can be used as a probe to monitor disturbed hepatobiliary transport in vivo and accumulation of bile acids in blood and liver during drug development.

Keyphrases

drug induced
liver injury
adverse drug
loop mediated isothermal amplification
high fat diet induced
quantum dots
living cells
pet imaging
type diabetes
label free
single molecule
pet ct