Engineering the TGFβ Receptor to Enhance the Therapeutic Potential of Natural Killer Cells as an Immunotherapy for Neuroblastoma.

Rachel A BurgaEric YvonElizabeth ChorvinskyRohan FernandesC Russell Y CruzCatherine M Bollard

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Our results support the development of "off-the-shelf" gene-modified NK cells, that overcome TGFβ-mediated immune evasion, in patients with neuroblastoma and other TGFβ-secreting malignancies.

Keyphrases

transforming growth factor
natural killer cells
nk cells
epithelial mesenchymal transition
genome wide
copy number
gene expression
genome wide analysis