Living Antimicrobial Wound Dressings: Using Probiotic-Loaded, Alginate Nanofibers for Protection against Methicillin-Resistant Staphylococcus aureus .

Living probiotic bacteria can be used as an alternative treatment to fight antibiotic-resistant, pathogenic bacteria. Electrospinning probiotics into nanofibers allows the probiotics to be conveniently applied like a wound dressing to protect open wounds while providing antimicrobial activity. In this letter, we encapsulated Lactococcus lactis into biocompatible, alginate-based nanofiber scaffolds. After cross-linking the scaffold to increase the chemical stability of the fibers, the encapsulated L. lactis cells maintained their ability to inhibit the growth of Staphylococcus aureus . This living wound dressing was especially effective at inhibiting the growth of clinically relevant methicillin-resistant S. aureus .