Population Modelling of Dexmedetomidine Pharmacokinetics and Haemodynamic Effects After Intravenous and Subcutaneous Administration.

Muhammad W Ashraf Panu Uusalo Mika Scheinin Teijo I Saari

Published in: Clinical pharmacokinetics (2021)

Our final model precisely describes dexmedetomidine pharmacokinetics and accurately predicts dexmedetomidine-induced sympatholysis and other pharmacodynamic effects. After subcutaneous dosing, dexmedetomidine is taken up into subcutaneous fat tissue, but our simulations indicate that accumulation of dexmedetomidine in this compartment is insignificant. CLINICALTRIALS.ORG: NCT02724098 and EudraCT 2015-004698-34.

Keyphrases

cardiac surgery
acute kidney injury
adipose tissue
high dose
high glucose
low dose
oxidative stress
molecular dynamics
drug induced
endothelial cells
monte carlo