BLT1 signaling in epithelial cells mediates allergic sensitization via promotion of IL-33 production.

Yingluo XiongXinyi CuiWenjing LiJiaoyan LvLixia DuWenli MiHuabin LiZhengrong ChenQibin LengHong ZhouRui He

Published in: Allergy (2018)

Our study reveals a functional role of LTB4-BLT1 axis in nonimmune cells, most likely lung ECs, in controlling allergic sensitization as an upstream regulator of IL-33.

Keyphrases

induced apoptosis
cell cycle arrest
allergic rhinitis
oxidative stress
cell death
cell proliferation