Gender Differences in the Effect of Calcitriol on the Body Disposition and Excretion of Doxorubicin in Mice.

Published in: European journal of drug metabolism and pharmacokinetics (2021)

The tissue concentrations and excretion of doxorubicin in both female and male mice are influenced by calcitriol without changes in the plasma pharmacokinetics. The results from this study can provide insights to help obtain the optimal drug combination effects of doxorubicin with calcitriol in cancer treatment.

Keyphrases

drug delivery
cancer therapy
skeletal muscle
adipose tissue
insulin resistance
drug induced
adverse drug