Acute Arterial Thrombosis of Lower Extremities in COVID-19 Patients.
Robert GlavinicLjiljana MarcicStipe DumancicMirela Pavicic IveljaIrena JeličićDanijela Kalibovic GovorkoIvana Medvedec MikićPublished in: Journal of clinical medicine (2022)
Clinical signs and symptoms of COVID-19 varied from asymptomatic forms to severe, life-threatening conditions that required treatment in intensive care units. These severe forms of illness are connected with a hypercoagulable state due to excessive inflammation, hypoxia, immobilisation, and altered angiotensin-converting enzyme 2 (ACE-2). In total, 17 COVID-19 positive patients were diagnosed with peripheral arterial thrombosis (AT), 13 of them had COVID-19 pneumonia. Laboratory findings in patients with X-ray confirmed pneumonia showed a four times higher neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP) and three times higher lactate dehydrogenase level (LDH) than patients without confirmed pneumonia. Patients with pneumonia had significantly more bilateral occlusions of the lower extremities and a significantly higher percentage with complete occlusion of the arteries than patients without pneumonia. The rate of limb loss was 35.3%. They were all from the group with COVID-19 pneumonia. Ten out of thirteen patients with pneumonia died due to acute respiratory distress syndrome (ARDS). All patients without pneumonia were discharged from the hospital. The aim of this retrospective study was to report the incidence of arterial thrombosis of lower extremities and their complications in the acute phase of the infection among COVID-19 patients admitted to the hospital for treatment.
Keyphrases
- sars cov
- coronavirus disease
- end stage renal disease
- ejection fraction
- acute respiratory distress syndrome
- newly diagnosed
- chronic kidney disease
- healthcare
- prognostic factors
- oxidative stress
- angiotensin converting enzyme
- magnetic resonance
- magnetic resonance imaging
- computed tomography
- high resolution
- mechanical ventilation
- mass spectrometry
- physical activity
- depressive symptoms
- adverse drug
- soft tissue
- case report
- liver failure
- sleep quality
- smoking cessation
- replacement therapy
- community acquired pneumonia