β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy.
Qiong ZhaoLu ChenXin ZhangHua YangYi LiPing LiPublished in: Chinese medicine (2024)
These results indicated that β-elemene improved cerebral ischemic injury and promoted the transformation of microglia phenotype from M1-like to M2-like, at least in part, through AKT/mTOR-mediated autophagy. This study demonstrated that β-elemene might serve as a promising drug for alleviating ischemic stroke injury.
Keyphrases
- signaling pathway
- cell proliferation
- cell death
- endoplasmic reticulum stress
- inflammatory response
- atrial fibrillation
- oxidative stress
- neuropathic pain
- subarachnoid hemorrhage
- cerebral ischemia
- emergency department
- ischemia reperfusion injury
- lps induced
- brain injury
- spinal cord injury
- spinal cord
- adverse drug
- drug induced