Adenovirus vectors activate Vδ2 + γδT cells in a type I interferon-, TNF-, and IL-18-dependent manner.

Nicholas M ProvineAli AminiLucy C GarnerMichael E B FitzPatrickChristina DoldLaura Silva ReyesSenthil ChinnakannanBlanche OgutiMeriel RaymondFulvia TroiseStefania CaponeAntonella FolgoriEleanor BarnesChristine S RollierAndrew J PollardPaul Klenerman

Published in: European journal of immunology (2022)

Vδ2 + γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2 + γδT cells in an interleukin 18-, TNF-, and type I interferon-dependent manner. This stimulatory capacity was associated with adenovirus vectors of non-species C origin, including the ChAdOx1 vaccine platform.

Keyphrases

gene therapy
rheumatoid arthritis
dendritic cells
regulatory t cells
immune response