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Adenovirus vectors activate Vδ2 + γδT cells in a type I interferon-, TNF-, and IL-18-dependent manner.

Nicholas M ProvineAli AminiLucy C GarnerMichael E B FitzPatrickChristina DoldLaura Silva ReyesSenthil ChinnakannanBlanche OgutiMeriel RaymondFulvia TroiseStefania CaponeAntonella FolgoriEleanor BarnesChristine S RollierAndrew J PollardPaul Klenerman
Published in: European journal of immunology (2022)
Vδ2 + γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2 + γδT cells in an interleukin 18-, TNF-, and type I interferon-dependent manner. This stimulatory capacity was associated with adenovirus vectors of non-species C origin, including the ChAdOx1 vaccine platform.
Keyphrases
  • gene therapy
  • rheumatoid arthritis
  • dendritic cells
  • regulatory t cells
  • immune response