Multi-regional sequencing reveals clonal and polyclonal seeding from primary tumor to metastases in advanced gastric cancer.
Yosuke HirotsuMasao HadaKenji AmemiyaToshio OyamaHitoshi MochizukiMasao OmataPublished in: Journal of gastroenterology (2020)
Clonal mutations were maintained at both the primary and metastatic sites and genetic divergence of these was low. These findings shed light on the genetic basis of primary tumor dissemination and metastatic processes in advanced gastric cancer.