SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts.
Theodoros KarampitsakosApostolos GalarisIlianna BarbayianniGiuseppe DeIuliisFarida AhangariFotis SampsonasVasilina SotiropoulouVassilis AidinisAnton M BennettJose D Herazo-MayaNikolaos XylourgidisBakakos PetrosDemosthenes BourosNaftali KaminskiArgyrios TzouvelekisPublished in: Diagnostics (Basel, Switzerland) (2023)
SHP2 attenuates fibrotic responses in fibroblast cell lines through negative regulation of mitochondrial metabolism and induction of autophagy. SHP2 activation may represent a promising therapeutic strategy for patients with fibrotic lung diseases.