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Combination Therapy With Canagliflozin Plus Liraglutide Exerts Additive Effect on Weight Loss, but Not on HbA1c, in Patients With Type 2 Diabetes.

Ali Muhammed AliRobert MartinezHussein Al-JoboriJohn AdamsCurtis TriplittRalph A De FronzoEugenio CersosimoMuhammad Abdul-Ghani
Published in: Diabetes care (2020)
These results demonstrate that liraglutide failed to block the increase in EGP caused by canagliflozin despite blocking the rise in plasma glucagon and preventing the decrease in plasma insulin concentration caused by canagliflozin. The failure of liraglutide to prevent the increase in EGP caused by canagliflozin explains the lack of additive effect of these two agents on HbA1c.
Keyphrases
  • combination therapy
  • weight loss
  • type diabetes
  • bariatric surgery
  • metabolic syndrome
  • obese patients