Enantioselective Friedel-Crafts Reaction of 2-Alkynyphenols with Aromatic Ethers by Chiral Brønsted Acid Catalysis.

Wenxuan ZhangJiaying SunZhendong LianRan SongDaoshan YangJian Lv

Published in: The Journal of organic chemistry (2022)

Herein, we report chiral strong Brønsted acid-catalyzed enantioselective Friedel-Crafts reaction of 2-alkynyphenols with aromatic ethers. The reaction affords the corresponding axially chiral styrenes in up to 91% yield and 97% ee.

Keyphrases

capillary electrophoresis
ionic liquid
amino acid
room temperature
electron transfer
mass spectrometry