Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival.
Ziena AbdulrahmanSaskia J A M SantegoetsGregor SturmPornpimol CharoentongMarieke E IjsselsteijnAntonios SomarakisThomas HölltFrancesca FinotelloZlatko TrajanoskiSylvia L van EgmondDana A M MustafaMarij J P WeltersNoel F C C de MirandaSjoerd H Van der BurgPublished in: Journal for immunotherapy of cancer (2022)
tumors constitutes a positive feedback loop to sustain the formation of the DC-T-cell microaggregates and identifies patients with excellent survival after standard therapy.